I have only slug hunted one time and would have never attempted a shot of that distance and on the run. During my deer season I hunt with dogs and we have to use buckshot. I have killed many deer on the run and feel comfortable shooting at a running deer if it is in range!! I do try if the deer is not at a fast run to try and stop it by giving a grunt sound or a wistle. My biggest deer to date was right at the distanse that I was not going to shoot at him unless I got him to stop, and he did.