Thanks ty...A good bolt action in .243, .25-06, 7mm-08, .270 or .30-06 is all you need...Top it with a decent 3x9x40 scope and you can kill any deer in Missouri....I have killed over 130 deer with my .243...but if you want something bigger and recoil is no problem its hard to beat a .270..
Factory ammo is readily avaliable anywhere they sell cartridges..Sight in 2 1/2 inches high at 100 yards with a good 130 gr bullet and you can hold dead on to 250...98% of the deer killed each year will be killed within 250 yards...And most hunters limit out each year within 150 yards...If you feel like a short action gun "fits" you better..Go with a 7mm-08...I have a brother that has killed a mess of deer with a Remington Model 7 in that caliber...shooting 140gr CoreLokts..

I would suggest .243, .270 and 7mm-08 over the 25-06 simply because most 25-06s have a longer barrel than a standard .270 and ammo isn't as readily avaliable, and selection isn't as good...Although a 30-06 is a great round...it does have more recoil than some hunters want...And once a hunter starts flinching its hard to get him to stop (or admit) and frankly a 30-06 is really more than is needed for most deer killed in the US...

That being said...if you happen to find a good deal on a 25-06 or a 30-06, and like the way the rifle handles and don't feel recoil of a 30-06 to be a problem either will do a fine job...Good Luck