I have gotten two cows so far this year - both with a muzzleloader. One was in Colorado - with a 410 grain Hornady Great Plains ahead of a MMP ballistic bridge sub base with 120 grains of 2F Triple 7. The second was in NM with a 250 Shockwave ahead of 130 grains of Pyrodex Pellets. Both were one-shot kills to the lungs - the first at 150 yards and the second at 137 yards. Both elk were on the ground in less than two seconds. Didn't recover either bullet. Have a couple of rifle tags coming up in the near future.