Almost any rifle will go through the rib cage and hit the vitals. Given the choice between the 7 Mag and the 22-250 for deer, I would take the 22-250 in a heartbeat. SLOW THAT 7 MAG DOWN TO 2700 FPS AND USE A BULLET WITH A HEAVIER JACKET LIKE THE 154 GRAIN hORNADY AND YOU WILL CUT DOWN A TON ON YOUR MEAT DAMAGE. hOWEVER AS THE OTHERS HAVE SAID, SHOT PLACEMENT IS THE KEY.MY 25-06 WILL DISTROY MEAT TOO IF YOU SHOOT A HIGH VELOCITY BULLET WITH A LIGHT JACKET AND HIT A BIGGER BONE. Opps hit the cap lock. Sorry about that.