I have used them to good luck with broadside shot deer, all one shot stops. I switched to the Sierra 100gr SBT becaue it was more accurate in my gun and killed as well or better. Between the two of them I really think the 100gr only holds the edge if you plan on shoulder breaking. I have put the 100gr SBT thru both shoulders on several big michigan whitetails. Federal loads both bullets in thier premium line, its a hell of a wolf bullet too.