I was torn between the 280 and 06 for my big game gun but picked the 06 because of the variety of factory ammo available was such an advantage. I did not handload at the time. If you reload the selection of bullets is like being a kid in the candy store for either but the number of loads worked up in the manuals still favors the 06.
The new 150 Grain TSX in the 280 makes me think twice however. for an all around big game load it has a great .529 BC and can be pushedat 3000 FPS with less recoil than my 165 Grain barnes 06 handloads.
A member of my gun club was shooting 1/2" groups and says it chronys 3000fps. He used 58 grains IMR 4831in hisWinchester Model 70.