If I'm reading correctly..you are talking about the bigger screws on the side of the bases....kinda like the Weaver type bases..If this is correct...the way I tighten both the Weaver type and the Rugers is to take a quarter and put in in your vise grips and tighten those screws until the quarter bends...If you will do this you don't need locktite and they won't come loose...