i have a remington 700 in 22-250 and i love it, i have heard barrel life is somewhat less than desireable but i have not found that to be my case, mine is over 15 years old,i dont shoot mine that often though, a friend of mine that does shoot often,shoots a 6mm, and he has been very happy, the only gun i keep out of my safe is a nef in .243, i keep it out for coyotes and stray dogs, before anybody gets excited we raise goats, and i don't need somebodies flea-bag relieveing me of 50-150$, the 243 is a great little caliber also, like has been mentioned a 223 has all kinds of ammo choices, it all boils down to what is the most important part of the equation, i think you'd enjoy any of those calibers, i reload and if you don't consider ammo cost[:@], and availibility, good luck let us know what you decide on.....