Well this leaves a lot of room for possiblities. The 22-250 is a great long range varmit cartridge but its wind bucking abilities would not be as good as say a 243 or better yet a 25-06. Leaning more toward the target end, I would go with a 308. I did a lot of target shooting with the 308 and often used it for long range prairie dog shooting. So I quess I would say the 25-06 if varmits are the main objective or the 308 if targets are the main goal. Don't overlook the Savage rifle when you start shopping. Its a low cost quality rifle.