It doesn't matter what size gun you shoot them with if you don't hit them right they WILL run off. We've shot them with everything from .223's to a .450 Marlin and if they were not hit right they will run off. A bigger gun helps if you don't make as good a shot but they can take a lot of bullets. I've personally had to crawl through the brush on my hands and knees to follow up a wounded 300lb hog that somebody shot with a .300 WM from 50 yards but hit it too far back. We heard it go down and it was thrashing around so we crawled in after it and after we got about 10 feet from it the hog got up and luckily ran the other way. The brush was so thick we couldn't move. So even though your gun is plenty big for hogs but you still need to hit them right.