It's hard to beat the smashing knock-down power of a 12 gauge slug! However, you will need an Improved cylinder choke and some sort of sight (fiber optic atleast). This would put ya in the game for some serious firepower. Here in IL we take out slug guns seriously.

Most use cantilever scope mounted fully rifled slug guns that shoot todays modern sabots into 4" or less groups at distances between 100 and 200 yards!