Well, I have tried them both with 130 grains of Pyrodex pellets - in my Black Diamonds and new Omega. The 300 shot acceptably, 250 shot great. Point of impact was very close in all three guns, with the 250's hitting an inch or so higher in each case. I shot an elk last year with the 300 grain and it worked pretty well. Afterseeing the picture (on this site) of the hole through a moose's shoulder put there with a 250 grain Shockwave, I'm looking forward to trying the 250 gr. SW during the New Mexico elk season a little later this fall. I'm betting it will work fine.