You are kidding me .22lr is not intimiding !! Come on dude we know trat that would not be the purpose at that point. If you are getting attacked all that is required is to get away not to blow body parts off. I have been shot with a duece-duece and it will not require you to dump a mag. full it to someones body to put them down . So your drug crazied 250lb man will go away with less then a hand cannon. Now lets talk about her being able to shoot it well ,I would suppose she could practice alot more and be more accurate then with a .45acp. Well all aside from this good luck and I hope you chose your weapon based on its intended use not for ego boosting.