Most 45s are more finicky shooters than 50-cals. If you haven't shot it yet, I'd suggest getting the 50 in an exchange. You can do-so even after cleaning the weapon. Just make everything look like it was when you opened the box.

The 50 does everything a 45 can do & more. It shoots all the same bullets a 45 does. It allows you more powder volumes with accuracy attached. It allows you to hunt slightly larger game because of the bigger bullet options. The 50 also gives tons of more ML accessories in stores.

If you reply with "I'm keeping the 45".... then othere here with 45-cal experiences will help you.