This is the ballistics read out of the 250 grain shockwave which starts at 1758 fps from the muzzle and is sighted in at 150 yards. As you can see for the real close shots you would be not too far off if you aimed dead center of the kill zone of the animal. Where you might have to keep in mind the ballistics is at 75 & 100 yard area where you might want to aim into the lower end of the kill zone because of the bullet rise... If people believe in the 600 fp of energy needed for a clean kill on a deer you can see that the bullet has a lot of power even at the longer ranges.

The real problem will boil down to how well you can shoot and hold groups at some of the extreme distances. I personally do not think a 125 yard shot is all that far but those that do the 200+ yard shots I am sure spend a great deal of time on the range before they would attempt such things. Also carry a set of shooting sticks, mount a bipod or have a blind with a good rest, it can make all the difference in the world.