My #1 choice is the 185 gr. Speer Gold Dot. Federal 230 gr.Hydro-Shock is also good, as frizzler suggested. I carry a .45 around all the time, and have shot a lot of critters with it over the years. Some of them, like a coyote, are very difficult to kill with a pistol. I have shot about a dozen with the 185 Gold Dot - as well as a couple of deer and a rogue rotweiler - puts them on the ground in a hurry.