First, if you have an 06, why would you need a 300 winmag or the 270? or vice versa, while performance will vary on trajectory all three will take any game on the NA continent with the exception maybe of a angry grizzly, the big bore lever gun has it's place in the thick woods and the 7mm08 is a nice easy recoiling cartridge try to find a ready supply of ammo without paying top dollar. As anyone will tell you shot placement and terminal performance of the bullet has more effect than the caliber used.