The best one is one that you can hit a softball with at 5 yards to 250 yards....if you can do that with a .243 to .338 Win Mag you are good to go....Close your eyes and pick one, then learn to shoot it...

What do I shoot??? .243 I bought in 1980...it has killed at least 130 whitetails, haven't lost a one....

But....I advise most to go with a .270...no need for any more....most don't or won't shoot a .270 enough to get really good with...Anything more just isn't needed.....

For strictly deer hunting, for a guy that doesn't reload...25-06, .270, 30-06, 7mm-08 or .308...Plenty of factory ammo, you would never know the difference if you hunted deer with all your life.