I think that people often times look at ballistic charts and overanalyze them. I shoot the 180 grainfailsafes in my '06 for all game from whitetail on up. The difference in velocity and trajectory are so minimal over normal hunting distances that I don't see the need to use the lighter bullet. I have never taken a shot over 300 yards in my life, and at these distance the heavier slug does just fine in the trajectory department. Some people will tell you that the lighter bullets expand better on game like deer, but I have never had a deer travel very far after being hit with that 180 grain failsafe, and I like knowing that the heavier slug will go through shoulders, ribs or whatever other bone it encounters on its way to the vitals.