I can't tell the difference between Hornady and Speer. Whichever is the least expensive at the time is what I buy up.
And, 50cal PRB will certainly do the trick on deer. For a stout load, try a wad on top of that 90gr 3FG then load your PRB. Also .018" ticking patch. You may just find exceptional accuracy out to 100 yards.
I always shoot wad's on top of the powder and a tighter patchfor heavy hunting loads.