RE: Big drop from 50 to 100 Yards...
Yes. For his case, to have same POI at 50 and 100, he would have to be 3" over center of bore to center of scope which I guess is possible if you have high see thru's. Thats considering 1800fps launch .18BC. Same as with a slug gun.
with standard 1.5" scope height, you would have to be-1.5" low at muzzle, 1" high at 50, 1" high at 75, and dead on at 100.
With see thrus, -3" low at muzzle, dead on at 50, 0.3" at 75, and dead on at 100.