I agree with the first two responses, a 180 TSX will out penetrate a 220grain lead nose "old school". There are some good 200s on the market, but they aren't gonna penetrate like the 180 Barnes. I assume you are wanting decent trajectory and great penetration since you are shooting heavy bullets from a 300? Like Roskoe said, years ago you had to go heavy to get the penetration and gave up some velocity and trajectory. The TSXs have done away with that "conundrum" (I believe that's what Alan Greenspan is callin it now?
).
You CAN have your cake and eat it to!
RA