I agree with sabotloader. There is nothing the .45 caliber can do that the .50 caliber can not match. There are a wider selection of projectiles for the .50 caliber and besides, it puts a bigger hole through the target. When shooting a .50 caliber sabot you have dropped your bullet diameter in many cases to a .44 or .45 caliber bullet. With a .45 caliber you have dropped even further to a .40 and .38 caliber bullet. Why go for a smaller hole? The difference in trajectory will mean nothing once you learn your load. Also a lot of people tell me they shoot long distances, but what do you really think the longest shot is you would normally take. A .50 caliber with practice is good out to 200 yards and has better knock down when it gets there. Also should you ever want to hunt is certain states, the .45 caliber is not allowed...

One last point that I can not say is true or false, but we used to read a lot of posts of people having a hard time finding a good shooting load for the .45 caliber. I am sure with the new projectiles and rifle designs, this is all changed now... Just a thought.