tda
Do not know what state you are in so I do not know your regulations, Here in Idaho we can use sabots - so the load that I would reccommend would have a sabot...
I am an avid elk hunter and have been hunting them all my life... got hooked on Nosler Partitions years ago with my 300 mag so noe that I have made the switch to ML's I haven't changed. I shoot 100 grains of t7-2f, 209-4 Remington primer, 300 grain .458 (45-70 rifle bullet) Nosler Partition in a MMP Orange 458/50 sabot. I am shooting either a Remiington M700ml or a Austin and Halleck. For me and in my two inlines these loads are really accurate and they do pack a punch...
Good luck in your search...