Since for instance you take a 100 grain load by volume and then weight that, and make all other loads to that weight, I see no reason why it would not work. I have thought of doing the same thing myself just to see if it would improve accuracy with the loads, but I have no scale to do that. It would be interesting to find the load your rifle likes, shoot a five shot group using just the powder measure as your guide and then repeating the same conditions with weighed charges and see if there was a large difference in accuracy....