A good comparison would be the Federal Vital Shok - Handgun Hunting Bullets. Only one listing per caliber, 41 mag - 250 g. , 44 mag - 300 g.
Both keep about equal velocity across the board.
The 44 mag. has about 20%more energy at 25 yards. 959 foot/pounds compared to 799 foot/pounds.
Which would you what as a last defence?