I don't hunt for coyotes but I often shoot them while deer hunting so its usually whatever I am hunting deer with. If I were to go out after coyotes I have a 223, 22-250, 243 and 25-06. I would use the 22-250 unless I was expecting really long shots. If so I would use the 243 with the 85 grain bullet or the 25-06 with the 90 grain Sierra BTHP GK.