ORIGINAL: HighDesertWolf
well I dont plan on hunting wyoming anytime soon, but if i had a few grand invested in a wyoming hunt. You bet your rear I will have the best cartrdige suited for those conditions something with a high ballistic coeffient and a alot of velocity for the least time of flight possible.
I'm thinking a 338 remington ultra mag loaded with lost river ballistics 250 grain J36 with about 100 grains of retumbo behind it.
I hunt in Wyoming all the time and I use a 7mm RUM with a 160gr Nosler Partition with 94 gr. of Retumbo powder.

It's fast, flat and generates it's own wind!

j/k
Growing up in Wyoming you learn how to shoot in it. I must admit the wind really whistles in Wyo., but it usually is very constant on direction which is nice. Overall though, most of us don't think about it much unless we are shooting long distances.