I could jump from the 224 to the 25's with no problem at all. I have a 243 but it sits around a lot anymore. I use the 223 or 22-250 for varmits and jump to 25 cal Minimum for deer and bigger game. However there are a jillion 243's around and I think they will stay around. I don't know how sales of the 243 WSSM are doing. I have not heard of anyone around here that has either the 223 or 253 WSSM. There are most likely a few though.