Throw a moose in then I would lean to the .450 but realize that these lightweight .450 carbines kick like a .375 H&H.
yes, it does have quite a kick. A friend of mine bought a .375 H&H and he shot my .450 one day and said he would prefer to shoot his .375. The .450 is like shooting a 12 gauge magnum shell, where hte .375 is a sharper punch.