Duke, Like some of the guys are saying, the 150 may be too 'tender' as they put it and may cause a good bit of meat damage, particularly if hit in the shoulder. If your worried about meat damage, try to avoid the shoulder and shot just behind it or, if close enough, a neck shot (except if you want the mount). A shot just behind the shoulder with a 150 gr bullet at 3000+ fps will cause horrific damage to the lungs and the hydroshock will be substantial.
If your shots are mostly out there at the 300 yd mark, I would go to a 180 gr bullet. I load my 300WM with 72 gr of IMR4350 behind a 180 Sierra Pro Hunter and a Rem 9 1/2 magnum primer.