I bought a new yote gun 6 months ago. I was pondering the same thing. I ended up going with the 22-250. Not for reasons of ammo either. At the time their were fewer guns available in 204. And the ones that were, commanded a higher price. Good old supply and demand. This was the first 22-250 I had bought. I am very pleased with it. Before I had used 223 and 220 swift. I can't really tell any difference between the 22-250 and the swift. Just that ammo is more afordable. Good luck