My favorite shot is a little different than what I've seen here. I don't like neck shots. spine shots ruin to much prime meat. I prefer a slightly quartering away shot with a rifle. The reason is I can take out both lungs and the offside shoulder. Works like a charm for me. If they do try to run they can't cover more than 40 or 50 yards carrying a shoulder. The shoulder meat is mostly hamburger and jerky meat anyway so if it gets a little shot up I don't mind. With a bow a double lunger is the only option in my mind. Of course I once used the deadly "texas brain" shot to harvest a whitetail.