I used my 22-250 to take a doe on a late season hunt. she wasnt far away tho, only about 20-25yards (coulda got her with my knife) I was there to kill limb rats (squirrels) because there were no signs of deer all season. then she walked out at daybreak, so i put it in her ear. 45gr 4000fps was moving, she didnt even finish the step she was taking.