I agree with most of the others here. The gap between a hunting gun, and a home defense gun, is too great to be filled by one gun, and/or caliber!
The "compromise," will leave you lacking on one end, or the other.
The .454/.45, or the .44mag/.44spl. are great for hunting, but over-penetration, and larger, unwieldy, guns for home defense.
On the other hand, the .357/.38spl. is marginal at best, as a hunting gun!
I'd suggest the Ruger Super Red Hawk, .44 mag. with the 7 1/2 inch barrel, and 2X scope as a good, affordable hunting rig.
For home defense, there are many affordable, 9MM semi-auto's, or .38spl. DA revolvers, that will stop an intruder, without taking out a family member, and neighbor along the way!
I know all this has been said before, but there is just not one gun choice that will fill both needs WELL!