Not totally. My expectation, and of course it's only an expectation, is that the bullet manufaturer takes into consideration the speed and energy of a particular cartridge when it designs how quickly it mushrooms. So is it possible that they would design two bullets of different caliber tomushroom similarly while passing through an animal? If that were the case since the 30-30 is a larger diameter the wound channel would be bigger.
As far as a 22-250 and a human. Im not sure the guts would be pushed at all.
I'm new at hunting and I can not say I am talking from experience. (only 2 shots with a 30-30 at deer). Both pass throughs by the way but in no way is that a lot of ecxperience.
I am only speaking from what I read