This question is akin to asking your boss "Well, do you want the work done fast or accurate"? Obviously the correct answer is there must be a balance of both. Everything must have it's limits. For me, I shoot out to 300 yards -- and no further. I can shoot my .338 RUM and be accurate to place a bullet in the kill zone consistently to this distance. Could I win a 1000 yard competition -- NO!

Having just been back from a Kodiak bear hunt (unsuccessful), I can assure you, a big Kodiak brownie is bigger than you imagine. I wear size 11 boots and put both feet in one track and still had room to spare, and that was a SOW!

There comes a point when hunting certain animals that more power is not only prudent, it may save your life, not to mention needless suffering of an animal. So...could a .243 kill a grizzly, sure it could! The only question is how long will it take to die and how fast can you run?