Well I'm assuming you're talking hunting and not target shooting because they are two entirely different things.

Let's say I'm shooting my trusty ole .308 and I'm getting 3 inch groups at 300 yds with it. Then I step up to a .300 winnie mag and now I'm getting 4.5 inch groups at 300 yds. Sure I've lost a little but from a hunting perspective I haven't lost a thing.

So to answer your question as long as what ever range I'm shooting at I have complete confidence I can hit the vital area in my opinion I've lost nothing.