I shot Central Texas whitetails with the 165 Sierra HPBT bullets. It was very deadly, giving fast one-shot knockdowns on them. BUT, I never did shoot a large mulie with one, so cannot comment there. I did shoot a 300+ pound mule deer buck once in northern New Mexico with a 140 Sierra 6.5mm PSPBT, and it did a real good job, but at over 200 yards (6.5X55mm Norwegian Krag, 24" bbl, MV 2650 FPS).

Keep yore powder dry!!