Let's get back to the original question, yes the .450 is great on the big animals.

It kills by putting a lot of lead in the animal by burning a lot of powder. A little bullet like the .270 also kills but uses speed to do the same. The problem is all that speed isn't going to do a darn bit of good if it; 1) is put on a fragile bullet that strikes a thick bone causing it to stop right there. 2) doesn't expand properly and keeps on going without doing much damage to the animals organs. That little .270 needs to expand to do any real damage because only by expanding is it going to deposit it's energy on the animal. The .450 hits the animal pre-expanded. It's also got a lot of weight behind it to keep it going deep into the vital organs. On top of all that it's going to expand allowing it to cause more damage.

Ignore the energy chart, it's all paper. When lead hits meat I'll rate the .450 as just as deadly as any .270, 30-06, .308, 7mm, or 300 mag.