I would have to say to go with the .300 Win Mag. 150 or 165 grain spitzer or BT's for deer, and load with a 200 grain premium bullet for grizzlies. I don't know what else would do much better, and still wouldn't cost an arm and a leg to shoot, and would destroy your shoulder everytime you shoot it. (Not to say the WM doesn't have any recoil, but it is certainly manageable by most people with a good stock and recoil pad).