No offense Swampman, but there are a zillion medium to long range calibers out there without going exotic. The key is long range and by that, I take it to mean over 300 yards. In that case the 7MM family from 7x57 to 7mag all come into play as well as the '06 and 308. You start shooting over 300 yards, and the bigger calibers are the only way to go IMHO. Necking a 375 h&h down to 7mm would be fine, but what are you really gaining???200fps?? Take a good look at the 7mmSTW loads...All that powder and shoulder misery for very little gain. Regards, Rick.