I dropped a deer from about 225 with a 30-30 but I wouldn't recomend it unless you had a stable rest, knew the exact range, and had lots of practice. I held over about 12 inches and put a 170 grains right where it's supposed to go. She ran for about 30 yards before slowing to a walk, took about a dozen more steps before dropping. Flat pointed bullets expand very well even at relativly slow velocities and this one did too. I found it lodged in the meat of the ribs opposite of the side I hit her.
The damage wasn't spectacular but her chest was still filled with blood.