I had two loads worked up for my whelen. One a 250 Hornady RN @ 2450fps and the other a 225 sierra SBT @ 2650. They would work with the same zero with the 225 hitting exactly 3" higher than the 250gr load. Varget and H322 were my perfered powders, along with rem cases and WLR primers. The 250 hornady load was extremely accurate. The only problem with the Nosler BT was that it seemed to generate exsessive pressures compared to the Sierra SBT. The barnes 225gr TSX is another bullet worth a good look. My loads always worked better with a crimp so I had a Lee "factory crimp" die custom made for the whelen, works great. The whelen is super easy to load for and a great old cartridge. Its spectacularly good at killing game without a lot of whizzbang and fanfair.