If you use your 25-06 the situation will go someting like this.

Saftey off
Squeeze the trigger
BOOM
Thud
Kick, kick, kick,
MMMMHHHHH backstrap

Nice! Thats my opinion too... I love my 25-06, it has been great on whitetails and Antelope and plan on totin it for mulies in the near future too..

LOL....yep that's much better. Seriously though there is a valid point I'm trying to make and I think you understand what I was trying to say.

To get back on topic though it's an ok deer cartridge. I know you asked a simple pass/fail question but I just can't asnwer that way. The 25-06 gets a C from me as far as deer cartridges go.

It's a classic deer cartridge, so its perfectly adequate.

Watched my cousin drop a mulie in its tracks with a .25-06, meanwhile the rest of us with .270s and .30-06 has mulitiple shots.

Plenty of power for a mulie, make a good shot and you'll have a dead deer.

I shot a 25-06 for years and killed pigs, mulies, black tails and white tails with it. I used Remington Core Lokt 100 gr bullets and literally rolled a 300lb white tail with it. I only went to a .300 Win Mag because some outfitters get nervous about the "small caliber." My daughter still shoots the 25-06 and has killed several animals, including BIG pigs with it. It's accurate as can be, you can shoot it all day long without pain and you don't lose the sight picture. Enjoy it, great choice!

removed by RD

You guys are all under gunned for mulies. You really need a 375 H&H to get the job done. Makes a good caliber when all you see is rump exiting stage left.

I have killed quite a few deer (whitetail and muley) using my 25-06 Wby. I love the gun and haven't had any trouble with it just wounding a deer. Of course, I am one hell of a shot too! :biggrin: But really it is probably my second favorite rifle in my gun cabinet next to my .270.

I had a Wichester M70 .25-06 with a Leupold 3.5-10X40 VariX III on it. I just shot 120 grain Wincheter CXP2 bullets through it since they were fairly cheap and the rifle liked them. I took around 20 mulies, 20 antelope, and 4 elk with it over 8 years. While I had other rifles at the time, I found myself picking this one up when it was time to go hunting since the recoil was tolerable and with a good rest (and not too much wind) I felt comfortable shooting out to perhaps 350 yards.

So yes the .25-06 has plenty of power for mule deer.

Good Luck and happy hunting! Mulies rock! I think you will have a memorable time!

would a barnes 100 grian be a better choice? i hear a barnes 100 grian hits like a 125-130 grian partition bullet.