oh it can happen. Not with a 22-250 or 270 or any other caliber.

If you could shoot a projectile at 8,000 FPS and could negate wind effect, it would never hit the ground. The bullet would fall at the same rate as the Earth's curvature.

The best way (that I am aware of) to sight in a rifle, first is to figure out how far you can expect to kill anything that you'd be willing to shoot at. If you won't shoot over 200 that fine, or if not over 400, that's fine too.

But you have GOT to know a very close approximation of the trajectory of your projectile, and you have GOT to know how far away your target is.

If you're willing to shoot at something 400 yards away (this is an example), sight it in at 400 yards. How do I do that? Sight it in at 100 for however good of a group I can get (5 shots, good cleaning after a 5 shot group, one minute apart in shots), then step back to 200 yard shots, adjusting only the top knob on the scope (not windage) till you're in a tight pattern at what you're shooting at. Then 300...same process. Then 400...same process.

When you're done at whatever range you're comfortable to shoot at something, put a target at 50, 100, 150, 200, 250, 300, and 350. Hold right on the target and see where the bullet goes. How much off at 50? at 200? With a flat shooting .270, you won't be much, if any out of a +/- 4" line off the aimed at target, above or below, at any point in the trajectory of the bullet.

Thus this is the tradeoff. Sight your gun in for 200 yards (dead on) and anything less than that you don't think about bullet trajectory. You put the crosshairs where you want and end it. BUT, you take a major risk shooting much farther than that. 300 is still a safe range, bullet is (from a handy ballistics chart) about -6.5 from the target on a 200 yard zero. That's pushing it, in my mind.

If you sight in your gun for a farther distance (which is up to each shooter, in my mind) then you need to know where your bullet is (vertically) on it's trajectory at points between you and the zero distance.