Take out the big brown bears and the 30'06 is my choice. I can't imagine shooting a WTD or antelope with one of those big magnums. Just sighting one in is brutal. Buy a 375 for the bear hunt, then put the scope back on the 30'06 and sell the magnum. If you can afford a bear hunt, you can afford a proper magnum for the job. just my 2 cents. good luck, Rick.