I did a fair bit of 200 yards shooting this spring/summer with my 50 cal inline. As a result I felt confident in my abilities and took my longest shot to date harvesting a Mulie Doe at 171 LRF, the bullet was dead in the centre of both lungs. Now it was a perfect morning with no real wind, knew the distance, my ML's Trajectory & also placed my pack on a rock which made a solid rest. FYI, my load was 100 T7 loose pushing a 250 gr SST, which I put in lots of time shooting all distances this year. If these factors weren't accounted for I would have never taken the shot, previous my longest was 147 yards.

Like anything it takes time, practice and knowing yours and the ML abilities. I also should mentioned my ML is scoped, with open sights I never would have attempted a shot of this length in a ML.