RE: 30.06 for deer
30-06, noooooo go againt the grain with a .243 ... I have downed 2 large whitetails with it, and never had a problem. It is extremely accurate. Both deer have dropped with in a second.
30-06 will do the trick just fine though. But i prefer the .243. You gotta shoot both of them and see which one feals the best/ more accurate.