RE: 45-70 in Africa.
I won't say that the .45-70 is a good choice for africa, but I won't say that a .243win is a good choice for moose, nor a .308win a good choice for black bear-but they've both been used for their respective game for years.
Ernst Hemmingway used a .30-06 back in 1936 over in Africa, for lions, buffalo (I haven't been able to find out if they were capes or water B's), and rhinos, Teddy Roosevelt also used a springfield on a nine month safari back in 1909-mostly for varied plains game and lion, both of which are well documented historically-you won't convince me that the .30-06 is a good choice for an african hunting round, but it's been used successfully.
There are now factory +P loads available for the .45-70 that push it to 3500ft.lbs., and I've seen reloading data that would push it nearer to 4000ft.lbs. (although I've never had reason to load it in any of my .45-70's.). Teddy Roosevelt also used the historic .405Winchester in the Winchester Model-1895 for many cape buffalo, the .405win pushed a bullet to 3300ft.lbs., so why is a .411" bullet at 3300ft.lbs. enough when a .458" bullet at 3300ft.lbs. isn't?
I've worked with American bison all of my life and hunted them a good deal as well. I won't say that bison are as tough as C.B.'s, even my experience can easily defeat that notion, however, mature bison can often outweigh mature C.B.'s by 15-25%, and I've successfully hunted them with a .44mag revolver, and I've seen countless prairie bison over the last 20yrs or so (you get paid by the gov't to do nothing more than feed them and maintain herd numbers) fall to .30WCF's. C.B.'s are tough, but they aren't immortal...you've even got a documented account in front of you that proves the .45-70 has more than enough penetration to kill two C.B.'s consecutively, why fight it?
Again, I won't say that it's a good choice, but it wouldn't necessarily be a terrible one...like I said, I'd never take it on my first hunting trip acrossed the pond (I've been over twice for photography "hunts" and as a photographer for two hunts my uncles went on-it's a lot cheaper to take snapshots than gunshots), but might consider it if I were to go back (BTW, my first hunting trip should be within two years=graduation present from my grandparents). A .223rem will kill deer if you place it right, but it won't kill by hydrostatic shock, so people favor something larger that will "stop them in their tracks", you're not going to kill a C.B. by hydrostatic shock from one shot at least-even if you're using a .458Lott, they mostly die from hemorhage or massive trauma, which the .45-70 can provide.